Abstract Search

ea0003p159 | Genetics | BES2002

Single nucleotide polymorphisms of the beta2-adrenergic receptor (ADRB2) gene and hypertension

Brain N , Tomaszewski M , Lacka B , Charchar F , Wang W , Padhmanaban S , Anderson N , Zukowska-Szczechowska E , Grzeszczak W , Dominiczak A

Objective: Three nonsynonomous SNPs, Arg16Gly, Gln27Glu and Thr164Ile, in the coding region of the ADRB2 gene affect either receptor affinity or trafficking. Their distribution has been shown to differ significantly in hypertension. We investigated the association of these loci with hypertension in the Silesian Hypertension Study.Methods: Following local ethics approval, 274 unrelated Polish subjects consisting of 146 hypertensives and 128 normotensives ...

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ea0029p35 | Adrenal cortex | ICEECE2012

Differential DNA methylation of the CYP11B1 and CYP11B2 genes in association with human adrenal zonation

Demura M. , Wang F. , Yoneda T. , Kometani M. , Sawamura T. , Cheng Y. , Ono K. , Nakamura Y. , Sasano H. , Saijoh K. , Takeda Y.

Background: The human adrenal cortex is composed of 3 distinct zones: the zona glomerulosa (ZG), the zona fasciculata (ZF), and the zona reticularis (ZR). Steroidogenic enzymes are expressed in a zone-specific manner. The promoters of CYP11B1 and CYP11B2 possess a number of target sites for DNA methylation that is closely associated with gene silencing.Methods and Materials: Adrenals from 5 autopsy subjects were assessed for immunohistrochemically define...

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Endocrine Abstracts

Single nucleotide polymorphisms of the beta2-adrenergic receptor (ADRB2) gene and hypertension

Differential DNA methylation of the CYP11B1 and CYP11B2 genes in association with human adrenal zonation

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